paquinimod treatment Search Results


paquinimod  (MedChemExpress)
95
MedChemExpress paquinimod
Blockade of S100a9 alleviates DSS-induced colitis in mice. Two groups of DSS-exposed mice ( n = 5) were treated with <t>paquinimod</t> (5 mg/kg) or PBS as controls every two days intraperitoneally. Two groups of none DSS-exposed mice ( n = 5) were also treated with paquinimod (5 mg/kg) or PBS as negative controls. ( a ) Gross macroscopic architecture of colonic tissues. ( b ) Colon length. ( c ) Relative body weight. ( d ) H&E staining analysis of colon tissues, scale bar: 50 µm. ( e ) IHC analysis of S100a9 , MPO and F4/80 , scale bar: 250 µm. ( f ) IHC staining score.
Paquinimod, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/paquinimod/product/MedChemExpress
Average 95 stars, based on 1 article reviews
paquinimod - by Bioz Stars, 2026-02
95/100 stars
  Buy from Supplier
paquinimod rescue assay  (TargetMol)
93
TargetMol paquinimod rescue assay
<t>Paquinimod</t> rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.
Paquinimod Rescue Assay, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/paquinimod rescue assay/product/TargetMol
Average 93 stars, based on 1 article reviews
paquinimod rescue assay - by Bioz Stars, 2026-02
93/100 stars
  Buy from Supplier
paquinimod  (Active Biotech)
90
Active Biotech paquinimod
<t>Paquinimod</t> rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.
Paquinimod, supplied by Active Biotech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/paquinimod/product/Active Biotech
Average 90 stars, based on 1 article reviews
paquinimod - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier

Image Search Results


Blockade of S100a9 alleviates DSS-induced colitis in mice. Two groups of DSS-exposed mice ( n = 5) were treated with paquinimod (5 mg/kg) or PBS as controls every two days intraperitoneally. Two groups of none DSS-exposed mice ( n = 5) were also treated with paquinimod (5 mg/kg) or PBS as negative controls. ( a ) Gross macroscopic architecture of colonic tissues. ( b ) Colon length. ( c ) Relative body weight. ( d ) H&E staining analysis of colon tissues, scale bar: 50 µm. ( e ) IHC analysis of S100a9 , MPO and F4/80 , scale bar: 250 µm. ( f ) IHC staining score.

Journal: Scientific Reports

Article Title: Identified S100A9 as a target for diagnosis and treatment of ulcerative colitis by bioinformatics analysis

doi: 10.1038/s41598-024-55944-3

Figure Lengend Snippet: Blockade of S100a9 alleviates DSS-induced colitis in mice. Two groups of DSS-exposed mice ( n = 5) were treated with paquinimod (5 mg/kg) or PBS as controls every two days intraperitoneally. Two groups of none DSS-exposed mice ( n = 5) were also treated with paquinimod (5 mg/kg) or PBS as negative controls. ( a ) Gross macroscopic architecture of colonic tissues. ( b ) Colon length. ( c ) Relative body weight. ( d ) H&E staining analysis of colon tissues, scale bar: 50 µm. ( e ) IHC analysis of S100a9 , MPO and F4/80 , scale bar: 250 µm. ( f ) IHC staining score.

Article Snippet: According to the instructions, the mice in the treatment group were intraperitoneally injected with paquinimod (MedChemExpress, ABR 25757) at 5 mg/kg every 2 days.

Techniques: Staining, Immunohistochemistry

Paquinimod rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.

Journal: Cell Host & Microbe

Article Title: Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

doi: 10.1016/j.chom.2020.12.016

Figure Lengend Snippet: Paquinimod rescues the mice infected by SARS-CoV-2 and MHV (A) A flow chart depicting the process of a drug rescue experiment. (B) Analysis of weight and survival rate of mice infected with SARS-CoV-2 and MHV after Paquinimod treatment. n = 6. (C) Analysis of the rescue effect of Paquinimod by H&E staining and pathology score of lung tissue in mice infected with SARS-CoV-2 or MHV at 5 dpi. Paquinimod treatment significantly prevented the bleeding and fibrosis in lung tissue. A number of pulmonary H&E staining images were randomly selected for pathological scoring. n = 10. Scale bars, 100 μm. (D) Immunohistochemical analysis of the S100A8 + cells in the lung tissue of mice infected with SARS-CoV-2 or MHV at 5 dpi after Paquinimod treatment. The S100A8 + cells in the lungs of mice infected with coronavirus were decreased significantly after Paquinimod treatment. The red arrows indicate the S100A8 + cells. n = 5. Scale bars, 50 μm. (E) qRT-PCR analysis for the expression of S100a8 and Ly6g in the lung of mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. n = 3. (F) qRT-PCR analysis of viral loads in the lungs of mice infected with coronavirus SARS-CoV-2 and MHV at 5 dpi after Paquinimod treatment. n = 3. (G) Flow cytometry analysis of neutrophils in lungs, blood, and bone marrow from mice infected with SARS-CoV-2 at 5 dpi after Paquinimod treatment. CD45 + CD11b + Ly6G variable aberrant neutrophils (P2) in the mice infected with SARS-CoV-2 were significantly decreased by Paquinimod treatment. n = 3. (H) Heatmap depicting a decrease in B cell-related gene expression in the lungs of mice infected with SARS-CoV-2. (I) qRT-PCR analysis for the expression of B cell marker gene Cd19 in the peripheral blood of mice infected with SARS-CoV-2 after Paquinimod treatment. n ≥ 5. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. Error bars, SD.

Article Snippet: For the Paquinimod rescue assay, all mice were challenged by viruses and randomly divided into two groups, in which one group was given intranasally 12.5 μg/day of Paquinimod (TargetMol; Catalog No. T7310) starting on 2 dpi and the other group was treated with equal volume PBS as the control group.

Techniques: Infection, Staining, Immunohistochemical staining, Quantitative RT-PCR, Expressing, Flow Cytometry, Marker

Journal: Cell Host & Microbe

Article Title: Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

doi: 10.1016/j.chom.2020.12.016

Figure Lengend Snippet:

Article Snippet: For the Paquinimod rescue assay, all mice were challenged by viruses and randomly divided into two groups, in which one group was given intranasally 12.5 μg/day of Paquinimod (TargetMol; Catalog No. T7310) starting on 2 dpi and the other group was treated with equal volume PBS as the control group.

Techniques: Recombinant, Lysis, Expressing, Software